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. 2019 Nov 25;10:2704. doi: 10.3389/fimmu.2019.02704

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Copyright © 2019 Nataf, Guillen and Pays.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mapping of the protein-protein interaction network linking common neurodegeneration-associated proteins irrespective of the cell type considered. A survey of the human proteome was performed by querying the protein-protein interaction database BioGRID (38). Each node represents a protein indicated by the corresponding gene symbol and each edge represents an experimentally-demonstrated protein-protein interaction. In this network, the “PRKN” (Parkin) node, highlighted in yellow, exhibits the highest degree (i.e., the highest number of direct interactors). White nodes correspond to the first-shell partners of PRKN. Gray nodes are not direct interactors of PRKN.