Figure 3.

Mapping of the protein-protein interaction network linking common neurodegeneration-associated proteins which are expressed in human B lymphocytes. A survey of the human proteome was performed by querying the protein-protein interaction database BioGRID (38). Each node represents a protein indicated by the corresponding gene symbol and each edge represents an experimentally-demonstrated protein-protein interaction. In this network, the “SQSTM1” (Sequestosome-1) node, highlighted in yellow, exhibits the highest degree (i.e., the highest number of direct interactors). White nodes correspond to the first-shell partners of SQSTM1 in human B lymphocytes. Gray nodes are expressed by B lymphocytes but are not direct interactors of SQSTM1.