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. 2019 Nov 25;10:2704. doi: 10.3389/fimmu.2019.02704

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Copyright © 2019 Nataf, Guillen and Pays.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mapping of the protein-protein interaction network linking common neurodegeneration-associated proteins expressed in B lymphocytes and their hub protein partners. A survey of the human proteome was performed by querying the protein-protein interaction database BioGRID (38). Only proteins expressed by human B lymphocytes according to the “Human Proteome Map” database (39) were taken into account. Each node represents a protein indicated by its corresponding gene symbol. The 4 hub proteins expressed by B lymphocytes and whose partners exhibit the most significant and highest enrichment factors in neurodegeneration-associated proteins are indicated in bold characters. White nodes correspond to neurodegeneration-associated proteins expressed by B lymphocytes and interacting with TRAF6. Gray nodes correspond to common neurodegeneration-associated proteins expressed by B lymphocytes but not reported to interact with TRAF6.