Table 1.
Expression patterns of human neurodegeneration-associated proteins in B-cells vs. dendritic cells.
| Gene symbol | Protein ID | Blood-derived B lymphocytes (39) | Blood-derived B lymphocytes (40) | Blood-derived DCs (41) | Cultured MoDCs (42) |
|---|---|---|---|---|---|
| APOE | P02649 | Detected | detected | 0 | 0 |
| APP | P05067 | Detected | 0 | 0 | 0 |
| ATXN2 | Q99700 | Detected | Detected | 0 | 0 |
| CHMP2B | Q9UQN3 | Detected | Detected | 0 | Detected |
| DCTN1 | Q14203 | Detected | Detected | 0 | Detected |
| FIG4 | Q92562 | Detected | Detected | 0 | 0 |
| FUS | P35637 | Detected | Detected | detected | Detected |
| GBA | P04062 | 0 | Detected | 0 | Detected |
| GRN | P28799 | Detected | Detected | 0 | 0 |
| HNRNPA1 | P09651 | Detected | 0 | 0 | Detected |
| HTT | P42858 | Detected | Detected | Detected | Detected |
| LRRK2 | Q5S007 | Detected | Detected | Detected | 0 |
| MATR3 | P43243 | Detected | Detected | Detected | Detected |
| OPTN | Q96CV9 | Detected | Detected | 0 | 0 |
| PARK7 | Q99497 | Detected | Detected | Detected | Detected |
| PFN1 | P07737 | Detected | Detected | Detected | Detected |
| PRPH | P41219 | Detected | 0 | 0 | Detected |
| PSEN1 | P49768 | Detected | 0 | 0 | 0 |
| SETX | Q7Z333 | Detected | Detected | 0 | Detected |
| SIGMAR1 | Q99720 | Detected | Detected | 0 | 0 |
| SNCA | P37840 | Detected | 0 | 0 | 0 |
| SOD1 | P00441 | Detected | Detected | Detected | Detected |
| SPG11 | Q96JI7 | Detected | Detected | 0 | 0 |
| SQSTM1 | Q13501 | Detected | Detected | 0 | Detected |
| TARDBP | Q13148 | Detected | 0 | Detected | Detected |
| TBK1 | Q9UHD2 | Detected | Detected | 0 | Detected |
| TBP | P20226 | Detected | Detected | 0 | 0 |
| TRPM7 | Q96QT4 | 0 | Detected | 0 | 0 |
| TUBA4A | P68366 | Detected | 0 | 0 | Detected |
| UBQLN2 | Q9UHD9 | Detected | Detected | 0 | 0 |
| UCHL1 | P09936 | Detected | Detected | 0 | 0 |
| VAPB | O95292 | Detected | Detected | Detected | Detected |
| VCP | P55072 | Detected | Detected | Detected | Detected |
| VPS35 | Q96QK1 | Detected | Detected | Detected | Detected |
The proteomics profiles of human circulating B lymphocytes, circulating dendritic cells (DCs) or cultured monocyte-derived dendritic cells (MoDCs) were retrieved from 4 independent mass spectrometry studies (39–42). We found that 34 from 48 common neurodegeneration-associated proteins were detected by mass spectrometry in at least 1 of the explored studies. Interestingly, 14 common degeneration-associated proteins (highlighted in gray) were reported to be detected in B lymphocytes but not DCs. These include notably apolipoprotein E, amyloid beta A4 protein, presenilin-1 and alpha-synuclein. In contrast, when detected in DCs, common neurodegeneration-associated proteins were constantly detected in B lymphocytes.