Table 7.

Enrichment analysis of the whole list of parent proteins giving rise to endogenous peptides binding HLA-DRB1 1501-encoded MHC class II molecules in the human B-cell lineage.

Term	Adjusted p-value
Disease enrichment
Neurodegenerative disease	7.8E-6
Influenza	2.1E-4
Allergic hypersensitivity disease	2.8E-4
Lupus erythematous	1.2E-3
inclusion-cell disease	1.6E-3
Gangliosidosis	1.6E-3
Diamond-Blackfan anemia	1.8E-3
Tetanus	2.0E-3
Lysosomal storage disease	2.3E-3
Dementia	3.1E-3

The “IEDB-AR” immune epitope database (43) was screened in order to retain only publications reporting on the systematic mass spectrometry identification of endogenous peptides binding MHC-class II molecules in the human B-cell lineage. Only results obtained in the absence of immunization or stimulation protocols were taken into account. The parent proteins from which derive the identified bound peptides were retrieved and the list of corresponding coding genes was submitted to an enrichment analysis with the “JENSEN Disease” text-mining webtool (37) embedded in the “Enrichr” analysis platform (36). Shown are the disease-related terms exhibiting the 10 most statistically significant enrichments. Terms relating with neurodegeneration are highlighted in gray.