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. 2019 Dec;29(12):1939–1950. doi: 10.1101/gr.254466.119

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© 2019 Hasegawa and Struhl; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 2. — Time-course ChIP-seq analysis. (A) Examples of human loci bound by TBP-ERT2 and yeast loci bound by 3HA-TBP (spike-in). (B) TBP-ERT2 binding to the composite average of Pol I, Pol II, and Pol III promoters relative to the 1440-min sample. (C) TBP-ERT2 binding relative to the 1440-min sample (left) and simulated relative TBP-ERT2 binding by using turnover rate (right) of all detected peaks. Peaks are ordered by turnover rate value (Lambda). (D) Examples of TBP-ERT2 binding and simulated data at the CYP20A1 (solid line) and POLR3E (dashed line) loci. (E) Scatter plot of log₂ TBP-ERT2 occupancy versus −log₁₀TBP-ERT2 binding turnover rate. (F) Histogram of the relative frequency of −log₁₀TBP-ERT2 binding turnover rate.