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. 2019 Dec;29(12):1939–1950. doi: 10.1101/gr.254466.119

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© 2019 Hasegawa and Struhl; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 6. — Pol III promoters with slow TBP binding dynamics have less nucleosomes and higher Pol III recruitment. (A) Scatter plot of TBP-ERT2 peaks annotated as Pol III genes in log₂TBP-ERT2 occupancy versus log₁₀TBP-ERT2 binding turnover rate. (B) Means and heat maps of TBP-ERT2 binding and DNase-seq signal on each target site near Pol III genes. (C) Means of MNase-seq (Sathira et al. 2010) signal along −1 kb to +1 kb from the TSS in each class. (D) Means of TB P-ERT2, Pol III (POLR3A), and Pol II binding (Choquet et al. 2019) along −1 kb to +1 kb from the TSSs of tRNA genes in each class. (E) Box plot of PRO-seq signal (Woo et al. 2018) at tRNA genes in each class.