Fig. 5. Plasma concentration–time profile of compound 19h following intraperitoneal (IP), intravenous (IV) and oral (PO) administration in mice. Blood samples were taken at different time points up to 135 min post-dose and analyzed for the total plasma concentration by LC-MS/MS analysis. The in vitro EC50 of 19h in H1975 cells (51 nM) is indicated.
