Fig. 6. (A and B) Co-crystal structures of covalent pyrrolopyrimidines in complex with EGFR-T790M/C797S mutant. Diagrams of the experimental electron densities of (A) 19g/EGFR-T790M/C797S at 2.7 Å (PDB ID: ; 6S89), (B) 19h/EGFR-T790M/C797S at 2.6 Å resolution (PDB ID: ; 6S8A); 2Fo-Fc map contoured at an r.m.s.d. of 1. (C) Alignment of 19g (orange) and 19h (green) in complex with EGFR-T790M/C797S and 29b in complex with cSrc-T338M/S345C (black outlined).