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. 2019 Nov 25;10:1399. doi: 10.3389/fphar.2019.01399

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Copyright © 2019 Lu, Wang, Sun, He, Wang, Wu, Liu, Wang and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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QSG inhibited the release of monocytes from the spleen. (A) HE staining showed that monocytes in the marginal zone of the spleen were released in the model group, and QSG could exert the protective effect by increasing the number of monocytes in red pulp under the capsule and marginal zone of the spleen. (B). QSG significantly decreased the circulatory level of angiotensin II. (C) Western blot showed that QSG reduced the expressions of AT1 and MCP-1 in splenic tissues. All data were presented as means ± SD from independent experiments performed in triplicate. ^## P < 0.01, ^### P < 0.001 vs the sham group; **P < 0.01, ***P < 0.001 vs the model group. N = 3 per group.