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. 2019 Nov 25;10:1399. doi: 10.3389/fphar.2019.01399

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Copyright © 2019 Lu, Wang, Sun, He, Wang, Wu, Liu, Wang and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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QSG promoted angiogenesis through inducing the number of M2 macrophages in myocardial tissue. (A) IF staining showed that QSG treatment up-regulated the M2 macrophages. After splenectomy, the number of M2 macrophages remained unchanged relative to the model group. (B) CD31 staining showed that QSG could promote angiogenesis. (C) Western blot showed that QSG increased the expressions of CD31 and VEGF in myocardial tissue compared with model group. All data were presented as means ± SD from independent experiments performed in triplicate. ^# P < 0.05 vs the sham group; *P < 0.05, **P < 0.01, ***P < 0.001 vs the model group. N = 3 per group.