Table 3.

Clinical Characteristics Of SPIDDM Compared With AT1D And T2D

	AT1D	SPIDDM	T2D
Age at diagnosis	Childhood to adolescence	Any age	Adulthood
Onset	Acute	Intermediate	Slow
Acute complications (e.g. ketosis) at diagnosis	Frequently	Rare	Rare
Micro/macro-vascular complications at diagnosis	Rare	Rare	Sometimes
Family history of diabetes	Sometimes	Sometimes	Frequently
Family history of autoimmune disease	Frequently	Frequently	Rare
Autoimmunity	Severely increased	increased	no change
Other autoimmune disease	Frequently	Frequently	Rare
HLA	Strongly associated	Associated	Not associated
BMI	Low to normal	Normal to high	High
Mets or its components	Rare	Sometimes	Frequently
Beta cell function	Severely decreased	Decreased	No change or increased
Decline in beta cell function	<3 months	>3 months	>years

Abbreviations: AT1D, acute-onset type 1 diabetes; SPIDDM, Slowly progressive type 1 (insulin-dependent) diabetes mellitus; T2D, type 2 diabetes mellitus; HLA, human leukocyte antigen; BMI, body mass index; Mets, metabolic syndrome.