Table 4.

Brain regional activation to alcohol- and cannabis-related words in contrast to neutral color words in alcohol use disorder (AUD) and control (CTL) subjects while performing an addiction Stroop color match-to-sample task. Activation clusters reported were significant at cluster-forming threshold corrected for multiple comparisons at level p < 0.05 voxels using a voxel threshold of p = 0.001.

Region		k extent	t value	MNI coordinates
	BA			x	y	z
Group differences
AUD < CTL
Alcohol (alcohol>color contrast)
L. dorsolateral prefrontal cortex	9	130	3.91	−30	32	38
R. dorsolateral prefrontal cortex	9	122	3.90	32	36	34
L. + R. middle frontal gyrus, premotor	6,8	205	3.85	2	28	40
Cannabis (cannabis>color contrast)
R. MFG, precentral	6,8,9	623	4.92	44	2	48
AUD>CTL
no supratheshold voxel
Within group effects
AUD
Alcohol < Color
L. middle frontal gyrus, premotor	6	445	5.60	− 34	0	56
L. + R. medial superior frontal gyrus, dACC	8	702	4.64	10	16	44
R. middle frontal gyrus, premotor	6	174	4.31	30	−2	60
L. lateral middle/superior frontal gyrus	6,8	150	4.28	− 38	2	34
R. dorsolateral prefrontal cortex	9	153	4.09	34	36	30
R. caudate		123	3.88	16	− 10	26
L. + R. dACC, SMA	6,24	118	3.81	−4	−6	50
Cannabis < Color (can<con)
R. dorsolateral prefrontal cortex, premotor	6,9	605	4.66	36	32	40
R. medial superior frontal gyrus	8	199	3.95	8	30	40
Cannabis > Color (can>con)
L. + R. calcarine V1, PCC	17,23	242	3.65	6	− 68	16
CTL
Alcohol vs. Color
no suprathreshold voxels
Cannabis > Color (can>con)
L. middle, superior temporal, angular gyri	21,39	202	4.30	− 54	− 42	8
L. superior parietal lobe	7	178	4.21	− 26	− 76	50
R. middle frontal gyrus	6,8	362	4.01	38	4	36

Abbreviations: BA = Brodman Area, L. = left, R. = right, dlPFC = dorsolateral prefrontal cortex, dACC = dorsal anterior cingulate cortex, PCC = posterior cingulate cortex.