. Author manuscript; available in PMC: 2019 Dec 3.

Published in final edited form as: J Med Chem. 2019 Mar 21;62(7):3354–3366. doi: 10.1021/acs.jmedchem.8b01785

Table 4.

Antimicrobial Activity against A. baumannii Strain 649 in the Presence and Absence of 25% Human Sera

	MIC(μM)
peptide name	no serum	25% human serum
With Specificity Determinants (Lys¹³Lys¹⁶)
D87(Lys¹-6 Arg-1)	0.7	1.3
D84(Lys¹-6 Lys-1)	0.3	0.3
D85(Lys¹-6 Orn-1)	0.4	0.2
D86(Lys¹-6 Dab-1)	0.7	0.2
Dl05(Lys¹-6 Dap-1)	0.8	3.0
Dl01(Lys¹Ser²⁶-5 Lys-1)	0.7	0.7
D102(Lys¹Ser²⁶-5 Dab-1)	0.4	0.7
Without Specificity Determinants (Ala¹³Ala¹⁶)
D85(K13A/K16A)-(Lys¹-6 Orn-1)	1.5	precipitate
D86(K13A/K16A)-(Lys¹-6 Dab-1)	0.8	3.0
D105(K13A/K16A)-(Lys¹-6 Dap-1)	0.8	12.5