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Extended R1 analogs of AT7519. A) CDK14 IC50s were measured using a LanthaScreen binding assay. IC50s were calculated as the average of three replicates, and are reported ± the standard errorB) Antiproliferative activity against the HCT116 cell line was measured using a CellTiter-Glo assay. IC50s were calculated as the average of three replicates, and are reported ± the standard error. –R is used to denote reversible control compounds (without an alkene group).
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