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Cellular target engagement of lead compounds in biotin pull-down assay, estimated based on testing of three compound concentrations.
| Compound | IC50 CDK14 (nM) | Compound | IC50 CDK14 (nM) |
|---|---|---|---|
| 9 | 1000 | 46 | 1000 |
| 36 | 500 | 10 | 50 |
| 75 | > 1000 | 57 | > 1000 |
| 56 | 1000 | 68 | > 1000 |
