Table 2. Relevant literature on CD200–CD200R1 mRNA or protein levels in neurodegenerative disorders, neurological sequelae of infections, or experimental peripheral inflammation in human or animal models.
| Neurological disorder | CD200 | CD200R1 | Areas | Endpoint | Model | Reference |
|---|---|---|---|---|---|---|
| Aging | Decreased | - | Hippocampus | Protein | Rattus norvegicus | [63] |
| Aging | Decreased | - | Hippocampus | mRNA | Rattus norvegicus | [64] |
| Aging | Decreased | - | Hippocampus | Protein | Rattus norvegicus | [65] |
| Aging | Decreased | - | Hippocampus | mRNA | Rattus norvegicus | [66] |
| Aging | Decreased | - | Substantia nigra | mRNA | Rattus norvegicus | [67] |
| Aging + Postoperative cognitive dysfunction | Decreased | - | Hippocampus | mRNA | Rattus norvegicus | [68] |
| Aging + Postoperative cognitive dysfunction | Decreased | - | Hippocampus | mRNA | Rattus norvegicus | [69] |
| Aging + Postoperative cognitive dysfunction | Decreased | Unchanged | Hippocampus | mRNA | Rattus norvegicus | [70] |
| Alzheimer's disease | Decreased | Decreased | Hippocampus/Inferior temporal gyrus | mRNA/Protein | Homo sapiens | [26] |
| Alzheimer's disease with Lewy bodies | Decreased | - | Temporal/Cingulate cortex | Protein | Homo sapiens | [71] |
| Chronic intractable epilepsy | Decreased | Unchanged | Cortex | mRNA/Protein | Homo sapiens | [72] |
| Dementia with Lewy bodies | Decreased | - | Temporal cortex | Protein | Homo sapiens | [71] |
| Influenza A/PR/8/34 (H1N1) virus | Decreased | - | Hippocampus | mRNA | Mus musculus | [73] |
| Influenza A/PR/8/34 (H1N1) virus | Decreased | - | Hippocampus | mRNA | Mus musculus | [74] |
| Multiple sclerosis | Decreased | Increased | Brain/Spinal cord | mRNA/Protein | Mus musculus | [75] |
| Multiple sclerosis | Decreased | Unchanged | Cortex/Spinal cord | mRNA/Protein | Homo sapiens | [76] |
| Parkinson's disease | Decreased | Decreased | Brain | Protein | Mus musculus | [77] |
| Parkinson's disease | Decreased | Decreased | Ventral midbrain | Protein | Mus musculus | [78] |
| Peripheral inflammation | Decreased | Decreased | Brain | mRNA | Mus musculus | [79] |
| Peripheral inflammation | Decreased | Increased | Substantia nigra | mRNA | Rattus norvegicus | [37] |
| Peripheral inflammation | Decreased | - | Hippocampus | mRNA | Mus musculus | [80] |
| Respiratory infection | Decreased | Increased | Hippocampus/Prefrontal cortex | mRNA | Sus scrofa | [81] |
| Stress and infection | Decreased | - | Hippocampus | mRNA | Rattus norvegicus | [82] |
| Theiler's virus-induced demyelinating disease | Decreased | Decreased | Spinal cord | mRNA | Mus musculus | [83] |
| Venezuelan equine encephalitis virus infection | Decreased | - | Brain | Protein | Mus musculus | [84] |
| Exitotoxic injury | Increased | - | Hippocampus | Protein | Mus musculus | [27] |
| Toxoplasma gondii encephalitis | Increased | Increased | Brain | Protein | Mus musculus | [52] |
| Prion disease | n.a. | Increased | Hippocampus | mRNA | Mus musculus | [85] |
| Acute stress | Unchanged | Decreased | Hypothalamus | mRNA | Rattus norvegicus | [86] |
| Depression | Unchanged | Decreased | Hippocampus | mRNA | Rattus norvegicus | [87] |
| Exitotoxic injury | Unchanged | - | Hippocampus | mRNA | Rattus norvegicus | [88] |
| Trypanosoma brucei infection | Unchanged | Unchanged | Brain | mRNA | Mus musculus | [89] |
Literature search was performed using Scopus and the PubTator text-mining tool by PubMed, searching for “CD200” and “Brain”. Articles focused on in vitro models, CNS neoplasias, and reviews were excluded.