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| EC50 (μM) | |
|---|---|
| WT (recombinant) | 7.1 ± 0.67 |
| Site 1 | |
| C780A | 3.3 ± 1.1 ** |
| C780Q | 12.8 ± 2.2 § |
| Site 2 | |
| C709A | not determined |
| C709Q | not determined |
The results shown are the mean and standard deviation of triplicate measurements. One representative result of three independent experiments is shown. The EC50 values were compared by Extra Sum-of-Squares F test in PRISM version 6 (GraphPad Software, Inc.).
**p < 0.01 and
§p = 0.0445, compared with WT.
