Table 3.
The associations between LS7 metrics and CVD-related biomarkers in women, n=2775
| hsCRP (mg/L) |
D-dimer (μg/mL) |
Fibrinogen (mg/dL) |
Homocysteine (μmol/L) |
hs-cTnT (ng/L) |
NT-ProBNP (pg/mL) |
IL-6* (pg/mL) |
|
| Smoking | |||||||
| Poor | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
| Intermediate | −0.07 (−0.51, 0.38) |
0.11 (−0.22, 0.44) |
0.03 (−0.05, 0.11) |
0.03 (−0.08, 0.14) |
0.005 (−0.17, 0.18) |
0.003 (−0.35, 0.36) |
0.03 (−0.22, 0.29) |
| Ideal | 0.02 (−0.12, 0.16) |
0.03 (−0.07, 0.13) |
−0.01 (−0.03, 0.02) |
−0.08
(–0.11,– 0.04) |
−0.01 (−0.07, 0.04) |
0.07 (−0.04, 0.18) |
−0.10
(–0.18,–0.02) |
| Body mass index | |||||||
| Poor | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
| Intermediate | −0.61
(–0.71,–0.51) |
−0.17
(–0.25,–0.10) |
−0.08
(–0.10,–0.07) |
−0.04
(–0.07,–0.02) |
−0.07
(–0.11,–0.03) |
0.06 (−0.03, 0.14) |
−0.34
(–0.40,–0.29) |
| Ideal | −1.15
(–1.25,–1.04) |
−0.32
(–0.40,–0.23) |
−0.14
(–0.16,–0.12) |
−0.06
(–0.08,–0.03) |
−0.09
(–0.14,–0.05) |
0.26
(0.17,0.35) |
−0.61
(–0.67,–0.55) |
| Physical activity | |||||||
| Poor | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
| Intermediate | −0.06 (−0.19, 0.07) |
0.05 (−0.05, 0.15) |
0.01 (−0.02, 0.03) |
−0.03
(–0.07,–0.00) |
−0.02 (−0.07, 0.03) |
0.01 (−0.09, 0.12) |
0.01 (−0.07, 0.08) |
| Ideal | −0.16
(–0.27,–0.06) |
−0.04 (−0.11, 0.04) |
−0.03
(–0.05,–0.02) |
−0.02 (−0.05, 0.00) |
−0.05
(–0.09,–0.005) |
0.04 (−0.05, 0.12) |
−0.10
(–0.16,–0.04) |
| Diet | |||||||
| Poor | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
| Intermediate | −0.16
(–0.25,–0.07) |
−0.02 (−0.09, 0.04) |
−0.01 (−0.02, 0.01) |
−0.002 (−0.02, 0.02) |
−0.01 (−0.05, 0.02) |
−0.01 (−0.09, 0.06) |
−0.10
(–0.15,–0.05) |
| Ideal | −0.40
(−0.74,−0.07) |
−0.09 (−0.33, 0.16) |
−0.02 (−0.07, 0.04) |
−0.07 (−0.16, 0.01) |
−0.11 (−0.24, 0.02) |
−0.05 (−0.32, 0.21) |
0.24
(−0.43,−0.06) |
| Total cholesterol | |||||||
| Poor | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
| Intermediate | 0.02 (−0.11, 0.14) |
−0.04 (−0.13, 0.05) |
−0.02 (−0.04, 0.00) |
−0.0001 (−0.03, 0.03) |
−0.01 (−0.06, 0.04) |
0.12
(0.02,0.21) |
0.09
(0.02,0.16) |
| Ideal | −0.08 (−0.21, 0.04) |
−0.02 (−0.11, 0.08) |
−0.06
(−0.08,−0.04) |
0.01 (−0.02, 0.04) |
−0.006 (−0.04, 0.06) |
0.24
(0.14,0.34) |
0.13
(0.06,0.20) |
| Blood pressure | |||||||
| Poor | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
| Intermediate | −0.13
(−0.24,−0.03) |
−0.05 (−0.13, 0.03) |
−0.003 (−0.02, 0.02) |
−0.005 (−0.03, 0.02) |
−0.09
(−0.13,−0.04) |
−0.28
(−0.37,−0.20) |
−0.07
(−0.13,−0.01) |
| Ideal | −0.45
(−0.56,−0.35) |
−0.11
(-0.19,−0.03) |
−0.02
(−0.04,−0.002) |
−0.04
(−0.07,−0.01) |
−0.12
(−0.16,−0.08) |
−0.30
(−0.39,−0.21) |
−0.21
(−0.27,−0.15) |
| Blood glucose | |||||||
| Poor | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) | 1 (reference) |
| Intermediate | −0.04 (−0.22, 0.14) |
0.01 (−0.13, 0.14) |
−0.01 (−0.04, 0.02) |
0.04 (−0.01, 0.08) |
−0.16
(−0.23,−0.09) |
0.10 (−0.04, 0.25) |
−0.0002 (−0.10, 0.10) |
| Ideal | −0.43
(−0.57,−0.28) |
−0.03 (−0.14, 0.08) |
−0.07
(−0.09,−0.04) |
0.002 (−0.03, 0.04) |
−0.19
(−0.25,−0.13) |
0.29
(0.17,0.40) |
−0.28
(−0.36,−0.20) |
*For IL-6, sample size=2733.
CVD, cardiovascular disease;hsCRP, high-sensitivity C-reactive protein; hs-cTnT, high-sensitivity cardiac troponin T;IL-6, interleukin 6; LS7, Life’s Simple 7; NT-proBNP, N-terminal pro B-type natriuretic peptide.