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. 2019 Nov 24;9(11):e031076. doi: 10.1136/bmjopen-2019-031076

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Protocol and follow-up of the SPCC. The baseline population of SPCC consisted of women and men at the periconception stage (couples who are preparing for pregnancy) and pregnant women at the early gestation stage. The cohort includes three phases, from periconception to birth (phase I, perinatal phase), from birth to 6 years (phase II, infant and preschool age) and from 7 to 18 years (phase III, school age). The current paper focuses on the first phase, with CHD as the primary outcome, and will cover other folate-sensitive birth defects. CHD, congenital heart disease; SPCC, Shanghai Preconceptional Cohort.