Fig. 2.
Anti-proliferative activity of graviola-derived annonamuricins A, B, C, D and annonacin against human prostate cancer cells (MTT assay). 60% confluent PC3 cells were incubated with the compounds at 20 μg/ml or positive control (LLnL, N-acetyl-L-leucinyl-L-norleucinal) at 1 μM for 24 h (annonamuricin A by 80% full PC3 cells for 48 h). DMSO served as solvent control. By LSD multiple comparison test in SPSS, the bioactive differences were labeled with A, B, C (at the 0.01 level), and d (at the 0.05 level).