Figure 3.

Recurrent mutations alter the AR cistrome. The benign LHSAR prostate cells were transfected with SPOP F113S or FOX A1 L445M expression plasmids or controls, and AR ChIP‐seq was performed 2 days later. Venn diagrams of shared and unique peaks compared to controls (A, D) demonstrate an expansion of ARBSs in each. Enrichment for Pomerantz T‐ARBSs and N‐ARBSs was performed for each experimental and control sample (B, E) and shows increased enrichment of T‐ARBSs. The percentage of TF motifs was determined for each sample (C, F) and shows different effects on motif occurrence. Statistical analysis of motif enrichment between groups was by chi‐square test using r software environment, and a P‐value of > 0.05 was considered significant as indicated by a *.