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Model system of the AMS. (A) In benign cells, AR is associated with c‐JUN and drives a transcriptome resulting in homeostasis. Various factors and mutations are able to shift the AR cistrome so that AR is associated with GATA2, FOXA1, and HOXB13 and drives a transcriptome resulting in proliferation. (B) Mutations (and their frequency in the TCGA dataset) that potentially cause the AMS and those that potentially provide a second hit necessary for transformation.
