Table 1.
Characteristics of 517 colorectal adenocarcinoma cases according to ITGA5 expression levels in TCGA cohort.
| Characteristicsa | All cases, | ITGA5 expression levels | P | |
|---|---|---|---|---|
| n = 517 | High expression, n = 258 (49.9%) | Low expression, n = 259 (50.1%) | ||
| Age | ||||
| > 68 | 247 (47.8%) | 118 (45.7%) | 129 (49.8%) | 0.354b |
| ≤ 68 | 270 (52.2%) | 140 (54.3%) | 130 (50.2%) | |
| Sex | ||||
| Men | 279 (54.0%) | 140 (54.3%) | 139 (53.7.8%) | 0.892b |
| Women | 238 (46.0%) | 118 (45.7%) | 120 (46.3%) | |
| Tumor location | ||||
| Proximal colon | 210 (40.6%) | 100 (38.8%) | 110 (42.5%) | 0.644b |
| Distal colon | 211 (40.8%) | 107 (41.5%) | 104 (40.2%) | |
| Rectum | 96 (18.6%) | 51 (19.8%) | 45 (17.4%) | |
| Local invasion depth | ||||
| T1/T2 | 115 (22.2%) | 43 (16.7%) | 72 (27.8%) | 0.002b |
| T3/T4 | 402 (77.8%) | 215 (83.3%) | 187 (72.2%) | |
| Lymph node involvement | ||||
| N0 | 302 (58.4%) | 138 (53.5%) | 164 (63.3%) | 0.041b |
| N1 | 122 (23.6%) | 64 (24.8%) | 58 (22.4%) | |
| N2 | 93 (18.0%) | 56 (21.7%) | 37 (14.3%) | |
| Distant metastasis | ||||
| M0 | 444 (85.9%) | 217 (84.1%) | 227 (87.6%) | 0.258c |
| M1 | 73 (14.1%) | 41 (15.9%) | 32 (12.4%) | |
| Tumor stage | ||||
| 0/I/II | 300 (58.0%) | 140 (54.3%) | 160 (61.8%) | 0.084b |
| III/IV | 217 (42.0%) | 118 (45.7%) | 99 (38.2%) | |
| Lymphatic invasion | ||||
| Yes | 193 (37.3%) | 105 (40.7%) | 88 (34.0%) | 0.114b |
| No | 324 (62.7%) | 153 (59.3%) | 171 (66.0%) | |
a
Percentages in all cases or in the corresponding subgroups (high expression or low expression) are given in the brackets. bχ2 test. cFisher’s exact test.