Table 3.
Hallmark gene sets significantly associated with high or low expression of subtype‐specific microRNAs in both the Oslo and TCGA cohorts.
| Upreg | AD PI | AD PP | AD TRU | |
|---|---|---|---|---|
| allograft_rejection | dna_repair | bile_acid_metabolism | ||
| complement | g2m_checkpoint | |||
| il2_stat5_signaling | myc_targets_v1 | |||
| il6_jak_stat3_signaling | myc_targets_v2 | |||
| inflammatory_response | glycolysis | |||
| interferon_alpha_response | oxidative_phosphorylation | |||
| interferon_gamma_response | ||||
| tnfa_signaling_via_nfkb |
| Downreg | AD PI | AD PP | AD TRU | |
|---|---|---|---|---|
| NA | allograft_rejection | e2f_targets | ||
| apoptosis | g2m_checkpoint | |||
| hedgehog_signaling | spermatogenesis | |||
| il2_stat5_signaling | myc_targets_v1 | |||
| il6_jak_stat3_signaling | myc_targets_v2 | |||
| inflammatory_response | unfolded_protein_response | |||
| interferon_alpha_response | mitotic_spindle | |||
| interferon_gamma_response | mtorc1_signaling | |||
| tnfa_signaling_via_nfkb | glycolysis | |||
| p53_pathway |
| Upreg | SCC Primitive | SCC Classical | SCC Secretory | SCC Basal |
|---|---|---|---|---|
| dna_repair | dna_repair | allograft_rejection | glycolysis | |
| e2f_targets | p53_pathway | inflammatory_response | estrogen_response_late | |
| g2m_checkpoint (prog cell cycle) | reactive_oxigen_species_pathway | il6_jak_stat3_signaling | ||
| mitotic_spindle | e2f_targets | complement | ||
| spermatogenesis | g2m_checkpoint | epithelial_mesenchymal_transition | ||
| myc_targets_v1 | unfolded_protein_response | angiogenesis | ||
| myc_targets_v2 | spermatogenesis | coagulation | ||
| oxidative_phosphorylation | myc_targets_v1 | myogenesis | ||
| myc_targets_v2 | kras_signaling_up | |||
| fatty_acid_metabolism | ||||
| glycolysis | ||||
| oxidative_phosphorylation | ||||
| cholesterol_homeostasis | ||||
| peroxisome | ||||
| mtorc1_signaling | ||||
| estrogen_response_late |
| Downreg | SCC Primitive | SCC Classical | SCC Secretory | SCC Basal |
|---|---|---|---|---|
| allograft_rejection | allograft_rejection | dna_repair | NA | |
| complement | inflammatory_response | g2m_checkpoint | ||
| inflammatory_response | complement | e2f_targets | ||
| il2_stat5_signaling | interferon_alpha_response | unfolded_protein_response | ||
| il6_jak_stat3_signaling | interferon_gamma_response | spermatogenesis | ||
| tgf_beta_signaling | il6_jak_stat3_signaling | myc_targets_v1 | ||
| tnfa_signaling_via_nfkb | epithelial_mesenchymal_transition | myc_targets_v2 | ||
| epithelial_mesenchymal_transition | angiogenesis | fatty_acid_metabolism | ||
| angiogenesis | coagulation | oxidative_phosphorylation | ||
| coagulation | myogenesis | glycolysis | ||
| heme_metabolism | kras_signaling_up | cholesterol_homeostasis | ||
| apoptosis | mtorc1_signaling | |||
| uv_response_dn | ||||
| myogenesis | ||||
| kras_signaling_up | ||||
| apical_junction | ||||
| androgen_response |