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. 2019 Oct 30;3(12):1598–1625. doi: 10.1002/hep4.1438

Figure 1.

Figure 1

Quantitative proteomic analysis identifies significantly down‐regulated lipid transporter proteins in SAH. (A) Partial list of proteins differentially regulated (>1.5‐fold; P < 0.05) between SAH, AC, HC, and its GO analysis, which documents enrichment of lipid transporters in SAH. (B) KEGG enrichment analysis of the up‐regulated (n = 32) and down‐regulated (n = 176) proteins in patients with SAH represents significant (P < 0.05) enrichment. (C) Plasma level of PON1 was down‐regulated in patients with SAH (median, 23.2; range, 2.3‐139.4) compared to those with AC (median, 44.7; range, 25.8‐131) and HC (median, 139.5; range, 46.6‐196.0) (P < 0.05). (D) Plasma level of apolipoproteins (APOB, APOE, APOA1, APOA2, APOC1, APOC3) in SAH compared to AC and HC (P < 0.05 is significant). (E) IHC showing expression of PON1, LDL, CD36, SRA1, ABCA1, and ABCG1 in SAH (n = 5) and AC (n = 5). For all IHC analyses, relative quantization of positively stained cells are expressed as mean number of positive cells/10 high‐power field (40×) and *P < 0.05. Abbreviations: COA, coenzyme A; HBG1, hemoglobin subunit gamma 1; KEGG, Kyoto Encyclopedia of Genes and Genomes; LBP, lipopolysaccharide binding protein; LPS, lipopolysaccharide; TLR4, toll‐like receptor 4;