Table 2.
Univariate and Multivariate Cox Regression Analysis of the Most Significant Parameters for the Determination of Mortality in Severe Alcoholic Hepatitis
| Variable | Significance* | HR | 95.0% CI for HR | |
|---|---|---|---|---|
| Lower | Upper | |||
| Univariate Analysis | ||||
| PON1 | 0.000 | 0.967 | 0.952 | 0.982 |
| APOB | 0.015 | 0.996 | 0.993 | 0.999 |
| APOE | 0.049 | 0.998 | 0.996 | 1.000 |
| APOA1 | 0.248 | 0.997 | 0.991 | 1.002 |
| APOA2 | 0.000 | 0.992 | 0.988 | 0.997 |
| APOC1 | 0.092 | 0.984 | 0.965 | 1.003 |
| APOC3 | 0.007 | 0.991 | 0.985 | 0.998 |
| PON1/APOB | 0.042 | 0.624 | 0.395 | 0.984 |
| PON1/APOE | 0.054 | 0.267 | 0.070 | 1.023 |
| PON1/APOA1 | 0.373 | 0.920 | 0.767 | 1.105 |
| PON1/APOA2 | 0.121 | 1.018 | 0.995 | 1.042 |
| PON1/APOC1 | 0.003 | 0.494 | 0.312 | 0.784 |
| PON1/APOC3 | 0.004 | 0.129 | 0.031 | 0.525 |
| Platelets | 0.001 | 0.481 | 0.309 | 0.748 |
| Sodium | 0.000 | 0.928 | 0.896 | 0.961 |
| TLC | 0.001 | 1.000 | 1.000 | 1.000 |
| Bilirubin | 0.102 | 1.021 | 0.996 | 1.046 |
| INR | 0.017 | 1.213 | 0.920 | 1.599 |
| CTP | 0.000 | 1.105 | 1.081 | 1.130 |
| MELD | 0.000 | 1.118 | 0.990 | 1.347 |
| SOFA | 0.000 | 1.469 | 1.347 | 1.603 |
| Variable | Significance | HR | 95.0% CI for HR | |
| Multivariate Analysis (parameters with original value) Model 1 | ||||
| PON1 | 0.000 | 0.934 | 0.917 | 0.952 |
| APOB | 0.001 | 0.995 | 0.992 | 0.998 |
| APOC3 | 0.007 | 0.995 | 0.991 | 0.999 |
| Platelet | 0.000 | 0.504 | 0.346 | 0.735 |
| TLC | 0.000 | 1.713 | 1.454 | 1.972 |
| INR | 0.024 | 1.282 | 1.033 | 1.591 |
| Variable | Significance | HR | 95.0% CI for HR | |
| Multivariate Analysis (parameters with derived values) Model 2 | ||||
| PON1/APOC1 | 0.047 | 0.852 | 0.796 | 0.895 |
| MELD | 0.000 | 1.072 | 1.033 | 1.112 |
| CTP | 0.000 | 1.133 | 1.098 | 1.169 |
| SOFA | 0.001 | 1.195 | 1.075 | 1.330 |
*
P < 0.05 is significant.
Abbreviation: CI, confidence interval.