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. 2019 Oct 14;3(12):1642–1655. doi: 10.1002/hep4.1430

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© 2019 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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BA metabolism and FXR/β‐catenin association are comparable in TG and WT mice after BDL. (A) Expression of SHP is increased in TG compared to WT mice after BDL, while Cyp7a1 and Cyp27 are unchanged before and after BDL. (B) Detoxification P450 enzymes are equivalently expressed in WT and TG mice after BDL. (C) BA uptake is unaffected by overexpression of β‐catenin after BDL. (D) Expression of apical and basolateral BA exporters are not different between WT and TG mice in response to BDL, with the exception of MRP3, which is decreased in TG compared to WT mice. (E) Total liver BAs are equivalent in TG and WT mice after BDL. (F) IP with β‐catenin shows maintenance of the FXR/β‐catenin complex in TG mice before and after BDL. For A‐E, *P < 0.05 and **P < 0.01 versus WT (t test). Data in the graphs represent mean ± SEM. Abbreviations: mRNA, messenger RNA; ns, not significant.