Table 3.
Association of Fibrosis Improvement Associated Sentinel SNPs With Improvement in Other Histological Phenotypes, ALT, and Pruritus
| rsid | CHROM | BEGIN | END | MARKER_ID | Fibrosis | Resolve | Improve | Steatosis | Lobular_inflammation | Portal_inflammation | Ballooning | ALT | Pruritus |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs12130403 | 1 | 154549470 | 154549470 | 1:154549470_T/C_Utr3:CHRNB2 | 5.76E‐05 | 0.090209 | 0.0028111 | 0.1488 | 0.083912 | 0.024397 | 0.38314 | 0.80754 | 0.94369 |
| rs6718351 | 2 | 35337270 | 35337270 | 2:35337270_C/G_Intron:AC012593.1 | 5.4E‐06 | 0.13877 | 0.0032052 | 0.21698 | 0.8466 | 0.67615 | 0.12519 | 0.11843 | 0.4273 |
| rs61588295 | 2 | 172532728 | 172532728 | 2:172532728_C/T_Intergenic | 1.11E‐05 | 0.14913 | 0.041331 | 0.26493 | 0.74642 | 0.50986 | 0.67555 | 0.65066 | 0.54445 |
| rs73138351 | 3 | 99159241 | 99159241 | 3:99159241_A/G_Intergenic | 4.81E‐06 | 0.0021231 | 0.004839 | 0.12206 | 0.53096 | 0.78479 | 0.051509 | 0.81376 | 0.32564 |
| rs11917264 | 3 | 189150773 | 189150773 | 3:189150773_A/G_Intergenic | 5.47E‐05 | 0.37456 | 0.087554 | 0.18451 | 0.89726 | 0.62822 | 0.059201 | 0.21756 | 0.37259 |
| rs4073431 | 11 | 26171987 | 26171987 | 11:26171987_A/T_Intergenic | 4.79E‐05 | 0.046251 | 0.086436 | 0.027919 | 0.52158 | 0.85299 | 0.79978 | 0.12502 | 0.7981 |
| rs59879172 | 13 | 71864207 | 71864207 | 13:71864207_T/G_Intergenic | 5.04E‐05 | 0.044179 | 0.58848 | 0.066344 | 0.74708 | 0.99385 | 0.6243 | 0.79135 | 0.92511 |
| rs1910560 | 18 | 26169692 | 26169692 | 18:26169692_T/G_Intergenic | 4.02E‐05 | 0.038593 | 0.005606 | 0.51667 | 0.12457 | 0.53761 | 0.06709 | 0.60546 | 0.4725 |
Bold values are statistically significant.
Abbreviation: CHROM, chromosome.