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. 2019 Oct 10;3(12):1656–1673. doi: 10.1002/hep4.1434

Figure 1.

Figure 1

Plasma concentrations of ALP, ALT, and AST. A single intraperitoneal injection of ACE2 vector treatment at (A‐C) established and (D‐F) advanced stages of biliary disease caused significant reductions in plasma levels of ALP, ALT, and AST compared to control vector‐treated animals and age‐matched control Mdr2‐KO animals. In support of this, animals treated for 4 weeks with Ang‐(1‐7) showed significantly reduced levels of plasma (G) ALP, (H) ALT, and (I) AST levels compared to saline‐infused disease‐control Mdr2‐KO mice, indicating that the treatment improved liver injury. Each bar represents the mean ± SEM profile from n = 12‐15 mice per treatment group and n = 5‐7 mice per Mdr2‐KO group without the vector.