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. 2019 Oct 10;3(12):1656–1673. doi: 10.1002/hep4.1434

Figure 2.

Figure 2

Gene expression of α‐SMA and collagen 1. (A‐D) α‐SMA and collagen 1 gene expression were significantly reduced by ACE2 therapy in both (A,B) established and (C,D) advanced biliary fibrosis compared to control vector‐injected Mdr2‐KO mice. (E,F) Similar to ACE2 treatment, Ang‐(1‐7) infusion significantly reduced their expressions in the liver of Mdr2‐KO mice whereas simultaneous infusion with MasR blocker A779 abrogated the effect of Ang‐(1‐7). Each bar represents the mean ± SEM profile from n = 12‐15 mice per treatment group and n = 5‐7 mice per Mdr2‐KO group without the vector.