Table 1.

Hepatic Inflammation and Fibrosis in Mdr2‐KO Mice Treated With ACE2 and Ang‐(1‐7)

Area of Inflammation/Fibrosis	Animal Groups
	Healthy Control	Mdr2‐KO + HSA‐rAAV2/8	Mdr2‐KO + mACE2‐rAAV2/8	Mdr2‐KO + Saline	Mdr2‐KO + Ang‐(1‐7)
Portal Inflammation	NI	1 ± 0.45	0.75 ± 0.37	1.8 ± 0.8	1.2 ± 0.54
Lobular Inflammation	NI	NI	NI	1.6 ± 0.7	0.4 ± 0.18*
Fibrosis	NF	3.4 ± 0.15	2.4 ± 1.07†	3.5 ± 1.56	1.4 ± 0.62‡

^* P < 0.05 versus saline‐infusion;

^† P < 0.05 versus control HSA vector injection;

^‡ P < 0.05 versus saline‐infusion. Histopathological assessment of fibrosis was made by using Metavir scoring.

Abbreviations: NF, no fibrosis; NI, no inflammation.