Table 5.
Incidence and hazard ratios of suicidal drug overdose in patients with epilepsy stratified according to the presence or absence of comorbid depression by Cox method.
| Variable | Comparison Cohort | Total Epilepsy | Epilepsy without Depression | Epilepsy with Depression |
|---|---|---|---|---|
| (N = 109,040) | (N = 54,520) | (N = 48,879) | (N = 5641) | |
| Person-years | 505,427 | 203,448 | 180,547 | 39.3 |
| Event, n | 196 | 932 | 709 | 223 |
| Rate # | 3.88 | 45.8 | 39.3 | 97.4 |
| Crude HR (95% CI) | 1(Reference) | 11.5(9.86, 13.4) *** | 9.84(8.40, 11.5) *** | 24.8(20.5, 30.1) *** |
| Adjusted HR $ (95% CI) | 1(Reference) | 10.6(8.99, 12.4) *** | 9.01(7.63, 10.6) *** | 22.9(18.7, 28.2) *** |
| Crude HR (95% CI) | 1(Reference) | 2.53(2.18, 2.94) *** | ||
| Adjusted HR $ (95% CI) | 1(Reference) | 2.56(2.17, 3.04) *** |
CI, confidence interval; HR, hazard ratio; # incidence rate per 10,000 person-years; $ multivariate analysis included age, monthly income, urbanization level, and comorbidity of schizophrenia, alcohol-related illness, anxiety, mental disorders, and insomnia; *** p < 0.001.