Table 3.

Summary of the magnitude of peripapillary RNFL thinning reported in a range of neurodegenerative diseases, as calculated by mean effect size.

Summary	Global	Superior	Temporal	Inferior	Nasal
Study
Alzheimer’s disease	++	++	+	++	++
Mild cognitive impairment	+	+	+	+	+
Parkinson’s disease	+	+	+	+	+
Optic Neuritis	+++	+++	+++	+++	++++
Multiple sclerosis	+	+	++	+	+
Amyotrophic lateral sclerosis	+	+	–	–	+

⁺1–10%, ++ 11–20%, +++ 21–30%, ++++ 31–40%.

ALS, amyotrophic lateral sclerosis.