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Antifibrotic effects of Nintedanib through the autophagy pathway. Nintedanib plays an antifibrotic role by inhibiting TGF-β signaling and downstream ECM secretion. Beclin-1-dependent and ATG7-independent autophagy is also involved in the process of Nintedanib antifibrotic action in the lung.
ECM, extracellular matrix; TGF-β, transforming growth factor β1.
