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Pulmonary arterial hypertension and autophagy pathway. GLP-1 regulates the level of autophagy via atg-5/atg-7/beclin-1-dependent pathways, and further participates in pulmonary vascular remodeling. Hypoxia affects the nucleation and elongation of autophagy by changing the expression levels of NF-κB and LC3, involved in the formation of PAH.
GLP-1, glucagon-like peptide-1; NF-κB, nuclear factor-kappaB; PAH, pulmonary arterial hypertension.
