Figure 1.

Workflow from GDC TARGET neuroblastoma CN data to finalized interchromosomal matrices used in the shiny application. Files are converted from GDC tab-delimited files with varying bin sizes into an input matrix of even 1 Mb bins and sample identifiers, and then into relationship metrics from linear regression (the negative log P-value). Postprocessing then sets the infinites to a high number to allow visualization and adds negative signs in regions where the strong relationship is an inverse linear relationship. Finally, the large, postprocessed matrix is converted to many small matrices with the ensembl-75 genes mapped to each genomic bin pair.

TARGET indicates Therapeutically Applicable Research to Generate Effective Treatments; CN, copy number; CNV, copy number variant.