Figure 3.

(A) Intrachromosomal association plot for chromosome 2. The box highlights a distinct feature on the diagonal indicating narrowing of the region of local co-association, and white lines emanating from that region show a reduction in association from the MYCN locus across all loci on the chromosome. (B) Enlarged view of the MYCN amplification domain with a break in linear regression signal near MYCN most likely due to amplification of MYCN in relatively small, often extrachromosomal, amplicons. The MYCN locus is highlighted.