Table 1.
Top variant identified by meta-analysis of genome-wide association analyses of age at completed suicide
| SNP | Chra | Positiona (bp) | Genea (location) | Effect allele (REF allele) | Stage | β b | s.e. | P value | P het c |
|---|---|---|---|---|---|---|---|---|---|
| rs73135307 | 7 | 73,869,857 | GTF2IRD1 (intronic) | G (C) | First set | −9.84 | 2.97 | 9.17 × 10−4 | |
| Second set | −15.6 | 3.39 | 4.15 × 10−6 | ||||||
| Meta-analysis | −12.3 | 2.23 | 3.25 × 10−8 | 0.20 |
Suggestive significance (P < 5.0 × 10−8) after meta-analysis of first and second set is shown in bold. Only top SNP in the same region is shown here. Full results (P < 1.0 × 10−6) can be seen in Table S6
Chr chromosome, bp base pair, REF reference allele
aPosition and gene are based on Human Genome version 19 (hg19), build 37
bβ were calculated by linear regression based on Wald tests implemented in Rvtests software
cP for heterogeneity between two analyses (first set and second set) were calculated by Cochran’s Q test