Figure 2.

Cholesterol interplay between mitochondria and cytosol. The Figure shows the major mechanisms of cholesterol influx (e.g., TSPO) into the mitochondria, exploited by the intracellular accumulation of APOE. The two isoforms of the transcription factor liver X receptor (LXR‐α and LXR‐β) are activated and hence translocated to the nucleus by the oxidized derivatives of cholesterol (oxysterols), which are formed by the high redox stress produced by malfunctioning mitochondria are also highlighted in the scheme