TABLE 3.
Diagnostic measures for EtG cutoff values of 100 and 500 ng/mL in 6211 PREVEND participants1
| Cutoff: 100 ng/mL (%) | Cutoff: 500 ng/mL (%) | |
|---|---|---|
| Total (n = 6211) | ||
| Sensitivity | 66.3 | 57.1 |
| Specificity | 92.3 | 96.0 |
| Positive predictive value | 96.3 | 97.8 |
| Negative predictive value | 47.4 | 42.5 |
| Proportion positive agreement | 78.5 | 72.1 |
| Proportion negative agreement | 62.7 | 58.9 |
| Impaired renal function [eGFR <90 mL/(min · 1.73 m2)] (n = 2425) | ||
| Proportion positive agreement | 75.6 | 68.7 |
| Proportion negative agreement | 66.4 | 63.1 |
| Normal renal function [eGFR ≥90 mL/(min · 1.73 m2)] (n = 3786) | ||
| Proportion positive agreement | 80.1 | 74.0 |
| Proportion negative agreement | 59.6 | 55.5 |
1
Comparison of diagnostic measures for different cutoff values of EtG concentrations. Sensitivity: TP/(TP + FN); specificity: TN/(TN + FP); positive predictive value: TP/(TP + FP); negative predictive value: TN/(TN + FN). eGFR, estimated glomerular filtration rate; EtG, ethyl glucuronide; FN, false EtG negatives; FP, false EtG positives; PREVEND, Prevention of Renal and Vascular End-Stage Disease; TN, true EtG negatives; TP, true EtG positives.