Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Nov 10;20(22):5622. doi: 10.3390/ijms20225622

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Pyruvate kinase M2 isoform (PKM2) silencing attenuates glycolysis in 786-O cells. (A) No significant changes were observed in oxygen consumption rate (OCR) after PKM2 expression knockdown. PKM2 knockdown also inhibited the basal respiration. (B) Proton efflux rate (PER) and basal glycolysis decreased after PKM2 expression knockdown by si156. (C) Proton efflux rate by glycolysis (glycoPER) and compensatory glycolysis decreased after PKM2 expression knockdown. (D) PKM2 knockdown significantly decreased total ATP production rate but increased the rate of mitoATP/glycoATP production.