Figure 6.

The agonist (e.g., bradykinin) binds bradykinin receptors. B1 and B2 receptors couple the PLC signaling pathway with a stimulatory effect (+) that triggers intracellular calcium release (↑ Ca²⁺), while B2 couples the AC signaling pathway with an inhibitory effect (-) that induces cAMP decrease (↓ cAMP). Additionally, B2 receptors also form dimers with D2 receptors (agonist – dopamine) and couple to AC signaling pathway increasing cAMP [83]. B2 receptors have high expression in some ovarian cell lines, while bradykinin levels are high in ascites of ovarian cancer patients.