| 1 Machine usage (hours/night) |
31 |
1452 |
Mean Difference (Fixed, 95% CI) |
0.21 [0.11, 0.31] |
| 2 Machine usage (hours/night) (Pepin imputed) |
32 |
1774 |
Mean Difference (Fixed, 95% CI) |
0.19 [0.10, 0.29] |
| 3 Number of participants who used CPAP therapy > 4 hours per night |
2 |
346 |
Odds Ratio (M‐H, Fixed, 95% CI) |
1.16 [0.75, 1.81] |
| 4 Machine usage (on nights when CPAP used 'effectively') |
3 |
|
Mean Difference (Fixed, 95% CI) |
0.42 [0.05, 0.78] |
| 5 Machine usage (frequency of usage as % of days) |
9 |
|
Mean Difference (Fixed, 95% CI) |
1.60 [‐0.83, 4.03] |
| 6 Machine usage (% of nights of > 4 hours of use) ‐ cross‐over studies |
2 |
|
Mean Difference (Fixed, 95% CI) |
6.25 [‐0.05, 12.54] |
| 7 Symptoms (Epworth Sleepiness Scale) |
25 |
1285 |
Mean Difference (Fixed, 95% CI) |
‐0.44 [‐0.72, ‐0.16] |
| 8 Withdrawals (parallel group trials/first arm cross‐over trials) |
13 |
1275 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.90 [0.64, 1.27] |
| 9 Quality of life (Functional Outcomes of Sleep Questionnaire) |
3 |
352 |
Mean Difference (Fixed, 95% CI) |
0.12 [‐0.21, 0.46] |
| 10 Quality of life (Sleep Apnoea Quality of Life Index) |
2 |
97 |
Mean Difference (Fixed, 95% CI) |
‐0.14 [‐0.54, 0.27] |
| 11 Quality of life (SF‐36 questionnaire) |
8 |
|
Mean Difference (Fixed, 95% CI) |
Subtotals only |
| 11.1 Physical functioning |
3 |
|
Mean Difference (Fixed, 95% CI) |
0.76 [‐3.50, 5.01] |
| 11.2 Role physical |
2 |
|
Mean Difference (Fixed, 95% CI) |
‐3.73 [‐13.46, 6.01] |
| 11.3 Bodily pain |
2 |
|
Mean Difference (Fixed, 95% CI) |
4.21 [‐4.23, 12.64] |
| 11.4 General health |
2 |
|
Mean Difference (Fixed, 95% CI) |
2.49 [‐4.99, 9.97] |
| 11.5 Vitality |
6 |
|
Mean Difference (Fixed, 95% CI) |
1.32 [‐1.25, 3.88] |
| 11.6 Social functioning |
2 |
|
Mean Difference (Fixed, 95% CI) |
3.31 [‐4.29, 10.92] |
| 11.7 Role emotional |
3 |
|
Mean Difference (Fixed, 95% CI) |
0.70 [‐4.19, 5.59] |
| 11.8 Mental health |
3 |
|
Mean Difference (Fixed, 95% CI) |
0.20 [‐1.88, 2.27] |
| 12 Apnoea Hypopnoea Index (events/hr) |
26 |
1256 |
Mean Difference (Fixed, 95% CI) |
0.48 [0.16, 0.80] |
| 13 Arousals (events/hr) |
4 |
136 |
Mean Difference (Fixed, 95% CI) |
‐0.66 [‐2.90, 1.58] |
| 14 Pressure of CPAP treatment (cmH2O) |
24 |
1171 |
Mean Difference (Fixed, 95% CI) |
‐1.01 [‐1.17, ‐0.84] |
| 15 Systolic blood pressure |
2 |
353 |
Mean Difference (IV, Fixed, 95% CI) |
1.87 [‐1.08, 4.82] |
| 16 Diastolic blood pressure |
2 |
353 |
Mean Difference (IV, Fixed, 95% CI) |
2.92 [1.06, 4.77] |
| 17 24‐hour mean BP |
2 |
530 |
Mean Difference (IV, Fixed, 95% CI) |
0.59 [‐1.05, 2.22] |
| 18 24‐hour systolic BP |
2 |
530 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.15 [‐2.21, 1.91] |
| 19 24‐hour diastolic BP |
2 |
530 |
Mean Difference (IV, Fixed, 95% CI) |
0.90 [‐0.65, 2.44] |
| 20 Diurnal mean BP |
2 |
530 |
Mean Difference (IV, Fixed, 95% CI) |
0.63 [‐1.05, 2.32] |
| 21 Diurnal systolic BP |
2 |
530 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.35 [‐2.44, 1.74] |
| 22 Diurnal diastolic BP |
2 |
530 |
Mean Difference (IV, Fixed, 95% CI) |
0.91 [‐0.74, 2.55] |
| 23 Nocturnal mean BP |
2 |
530 |
Mean Difference (IV, Fixed, 95% CI) |
0.43 [‐1.29, 2.15] |
| 24 Nocturnal systolic BP |
2 |
530 |
Mean Difference (IV, Fixed, 95% CI) |
0.88 [‐1.81, 3.57] |
| 25 Nocturnal diastolic BP |
2 |
530 |
Mean Difference (IV, Fixed, 95% CI) |
0.80 [‐0.81, 2.40] |
| 26 Tolerability outcomes |
1 |
|
Odds Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
| 26.1 Intolerable treatment pressure |
1 |
|
Odds Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 26.2 Mask leak |
1 |
|
Odds Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 26.3 Dry mouth |
1 |
|
Odds Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 26.4 Stuffy nose |
1 |
|
Odds Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 27 Patient preference (auto‐CPAP/not auto‐CPAP) |
14 |
|
Odds Ratio (M‐H, Random, 95% CI) |
Totals not selected |
