Comparison 2. Bi‐PAP versus fixed CPAP.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Machine usage (hours/night)	4	268	Mean Difference (Fixed, 95% CI)	0.14 [‐0.17, 0.45]
2 Symptoms (Epworth Sleepiness Scale)	4	226	Mean Difference (Fixed, 95% CI)	‐0.49 [‐1.46, 0.48]
3 Withdrawals (parallel group trials/first arm cross‐over trials)	3	261	Odds Ratio (M‐H, Fixed, 95% CI)	0.55 [0.26, 1.17]
4 Quality of life (Functional Outcomes of Sleep Questionnaire)	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
5 Quality of life (Sleep Apnoea Quality of Life Index)	1		Mean Difference (Fixed, 95% CI)	Totals not selected
6 Quality of life (SF‐36 questionnaire)	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
6.1 Physical health	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
6.2 Mental heath	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
7 Apnoea Hypopnoea Index (events/hr)	2	179	Mean Difference (Fixed, 95% CI)	1.36 [‐6.92, 9.63]
8 Patient preference ‐ BiPAP/no preference or CPAP	2		Odds Ratio (M‐H, Fixed, 95% CI)	Totals not selected
9 Tolerability outcomes	1		Odds Ratio (M‐H, Fixed, 95% CI)	Totals not selected
9.1 Dry mouth	1		Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
9.2 Mask intolerance	1		Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
10 Treatment comfort score	1		Mean Difference (Fixed, 95% CI)	Totals not selected