Bakker 2010.

Methods	Randomised, double‐blind, parallel group study
Participants	N = 76 participants (53 M/23 F). Age not reported. BMI 35.6 kg/m2; AHI 60.2; ESS 13.6 Inclusion criteria: CPAP naive Exclusion criteria: significant cardiac, respiratory, psychiatric, or sleep comorbidities
Interventions	CPAP versus C‐Flex (identical devices) Study duration: 3 months
Outcomes	Machine usage (average hours used and average days used) Quality of life (FOSQ and SF‐36) AHI Symptoms (ESS) Withdrawals Treatment pressure Tolerability (mask leak)
Funding & conflicts of interest statements	'This study was funded by Philips‐Respironics. All authors received research support from Philips‐Respironics. Philips‐Respironics manufactures and markets CPAP and C‐Flex devices.'
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "Randomization to treatment was performed prior to manual titration using a (1, 2) urn randomization procedure"
Allocation concealment (selection bias)	Low risk	Quote: "Randomization to treatment was performed prior to manual titration using a (1, 2) urn randomization procedure"
Blinding of participants and personnel (performance bias) Machine usage, symptoms, quality of life, withdrawal, adverse effects	Low risk	Quote: "The study was a double‐blinded, parallel‐arm RCT of C‐Flex versus CPAP" Quote: "Patients were not able to access the C‐Flex menu option, and all references to "C‐Flex" on the device were covered"
Blinding of participants and personnel (performance bias) AHI, blood pressure, treatment pressure	Low risk	Quote: "The study was a double‐blinded, parallel‐arm RCT of C‐Flex versus CPAP" Quote: "Patients were not able to access the C‐Flex menu option, and all references to "C‐Flex" on the device were covered"
Blinding of outcome assessment (detection bias) Machine usage, symptoms, quality of life, withdrawal, adverse effects	Low risk	Identical machine appearance unlikely to affect measurement of these outcomes
Blinding of outcome assessment (detection bias) AHI, blood pressure, treatment pressure	Low risk	Quote: "The data analyst remained blinded by random 3‐digit codes being assigned to all patients"
Incomplete outcome data (attrition bias) All outcomes	Low risk	Quote: "Two patients were withdrawn".........2 patients dropped out of the CPAP group............they were replaced with additional recruitment, and therefore analysis was conducted on a per‐protocol basis"
Selective reporting (reporting bias)	Low risk	All outcomes reported
Other bias	Low risk	No concerns identified