d'Ortho 2000.

Methods	Randomised, single‐blind, cross‐over study. Method of randomisation: random sampling number tables (correspondence with trialist). All participants accounted for Data analysis: paired t test where ANOVA significant. T test used for treatment pressure. Analysis on usage not paired t test.
Participants	N = 25 participants (22 M/3 F). Mean age 57; mean AHI 57.8 Inclusion criteria: OSA confirmed by PSG; AHI > 10/hr; ATS recommended indication for CPAP treatment
Interventions	Auto‐CPAP versus fixed CPAP. No washout period Study duration: 2 x 4 week treatment arms
Outcomes	Machine usage (average hours used) AHI Treatment pressure Tolerance to CPAP (questionnaire scoring system) Symptoms (ESS) Preference
Funding & conflicts of interest statements	Funded by Institut National de la sante et de la Recherche Medicale & by Nellcor‐Puritan Bennett. No declaration of interests provided.
Notes	—
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Random sampling number tables
Allocation concealment (selection bias)	Unclear risk	Information not available
Blinding of participants and personnel (performance bias) Machine usage, symptoms, quality of life, withdrawal, adverse effects	High risk	Quote: "Patients were not aware of the order of administration (i.e. they were blinded to the setting mode until the first night of use after which they could easily guess which mode they were using.).........The questionnaire was completed with the help of sleep laboratory technicians who were unaware of CPAP mode."
Blinding of participants and personnel (performance bias) AHI, blood pressure, treatment pressure	Low risk	Awareness of treatment group assignment unlikely to affect objective outcome data from the study
Blinding of outcome assessment (detection bias) Machine usage, symptoms, quality of life, withdrawal, adverse effects	High risk	Quote: "Patients were not aware of the order of administration (i.e. they were blinded to the setting mode until the first night of use after which they could easily guess which mode they were using.).........The questionnaire was completed with the help of sleep laboratory technicians who were unaware of CPAP mode."
Blinding of outcome assessment (detection bias) AHI, blood pressure, treatment pressure	Low risk	Awareness of treatment group assignment unlikely to affect objective outcome data from the study
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants accounted for
Selective reporting (reporting bias)	Low risk	All outcomes reported
Other bias	Low risk	No concerns identified