Hussain 2004.

Methods	Randomised, single‐blind, cross‐over study. Method of randomisation not described. Statistical test: paired t tests
Participants	N = 10 (9 M/1 F). Mean age: 44.98; AHI: 47.2; BMI: 35.9; ESS: 11.1 Inclusion criteria: CPAP‐naive at baseline; symptomatic OSA (AHI > 15/h) Exclusion criteria: not described
Interventions	Auto‐CPAP versus fixed CPAP Study duration: 2 x 4‐week treatment periods (washout 2 weeks)
Outcomes	Machine usage (average hours used) Symptoms (ESS) AHI Treatment pressure Preference Polsomnography outcomes
Funding & conflicts of interest statements	Quote: "This study was funded by Respironics Inc., Murrysville, PA." Author conflicts of interest: not declared
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Information not available
Allocation concealment (selection bias)	Unclear risk	Information not available
Blinding of participants and personnel (performance bias) Machine usage, symptoms, quality of life, withdrawal, adverse effects	High risk	Quote: "...this randomized, prospective, single‐blind cross‐over trial.....Patients were unaware of the treatment mode..."
Blinding of participants and personnel (performance bias) AHI, blood pressure, treatment pressure	Low risk	These outcomes unlikely to be affected by single‐blind study design.
Blinding of outcome assessment (detection bias) Machine usage, symptoms, quality of life, withdrawal, adverse effects	High risk	Study personnel would have been aware of treatment group assignment.
Blinding of outcome assessment (detection bias) AHI, blood pressure, treatment pressure	Low risk	These outcomes unlikely to be affected by single‐blind study design.
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants completed
Selective reporting (reporting bias)	Low risk	All outcomes reported
Other bias	Low risk	No concerns identified