Reeves‐Hoché 1995.

Methods	Randomised, parallel group trial
Participants	N = 83 (gender available for 62 completers: 45 M/17 F). Mean age: 47; BMI: 40 kg/m2; AHI: 51 Inclusion criteria: OSA diagnosed according to American Sleep Disorders Association AHI > 10; "heavy snoring"; excessive daytime sleepiness Exclusion criteria: concomitant illness requiring hospitalisation 6 months previously; psychiatric illness; pregnancy
Interventions	Bi‐PAP versus CPAP administered at home Study duration: 52 weeks Prescribed inspiratory pressure was 11 mmHg ± 0.3 and expiratory pressure was 7 mmHg ± 0.3 in the BiPAP group versus 10 mmHg ± 0.2 in the fixed CPAP group at baseline
Outcomes	Machine usage Withdrawals Tolerability
Funding & conflicts of interest statements	'Supported in part by Respironics'. Author conflicts not provided.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated numbers
Allocation concealment (selection bias)	Unclear risk	Information not available
Blinding of participants and personnel (performance bias) Machine usage, symptoms, quality of life, withdrawal, adverse effects	Unclear risk	Information not available
Blinding of participants and personnel (performance bias) AHI, blood pressure, treatment pressure	Low risk	These outcomes unlikely to be affected by awareness of treatment group.
Blinding of outcome assessment (detection bias) Machine usage, symptoms, quality of life, withdrawal, adverse effects	Unclear risk	Information not available
Blinding of outcome assessment (detection bias) AHI, blood pressure, treatment pressure	Low risk	These outcomes unlikely to be affected by awareness of treatment group.
Incomplete outcome data (attrition bias) All outcomes	High risk	Non‐completers did not contribute to analysis
Selective reporting (reporting bias)	Unclear risk	Information not available
Other bias	Low risk	No concerns identified