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. 2019 Dec 2;2019(12):CD003531. doi: 10.1002/14651858.CD003531.pub4

Sériès 2001.

Methods Randomised, parallel group trial
Participants N = 48. 40 had previously participated in other trials of auto and fixed CPAP. Mean age: 48; BMI: 39.5 kg/m2
Inclusion criteria: PSG‐diagnosed OSA
Exclusion criteria: corrective surgery for OSA
Interventions Auto‐CPAP (Morphée) versus fixed CPAP
Study duration: 3 weeks
Outcomes

  1. Machine use (average hours used)

  2. Symptoms (ESS)

  3. AHI

  4. Withdrawals
Funding & conflicts of interest statements Not provided
Notes TJL emailed for details of randomisation and outcome data 8 September 2008.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Computer‐generated random sequence
Allocation concealment (selection bias) Low risk Quote: "This was done using a binary randomisation list provided by our statistician who was not involved in the study."
Blinding of participants and personnel (performance bias) 
 Machine usage, symptoms, quality of life, withdrawal, adverse effects High risk Some participants had previously participated in a study and could have become aware of different devices irrespective of masking treatment group assignment
Blinding of participants and personnel (performance bias) 
 AHI, blood pressure, treatment pressure Low risk These outcomes unlikely to be affected by awareness of treatment group.
Blinding of outcome assessment (detection bias) 
 Machine usage, symptoms, quality of life, withdrawal, adverse effects High risk Some participants had previously participated in a study and could have become aware of different devices irrespective of masking treatment group assignment
Blinding of outcome assessment (detection bias) 
 AHI, blood pressure, treatment pressure Low risk These outcomes unlikely to be affected by awareness of treatment group.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Most outcomes in this review unaffected by the following exclusions:
Quote: "The sleep stage‐ and body position‐dependence could not be characterized in 15 patients who did not change body position or whose sleep architecture did not include REM sleep during baseline sleep recording. These subjects were therefore excluded from the comparison between sleep stages/body position‐dependent and independent patients."
Selective reporting (reporting bias) Low risk All outcomes reported
Other bias Low risk No concerns identified